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Last updated on 2021-01-15.

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Mickaël Canouil

Curriculum Vitæ

I’m currently working for the Institut Pasteur de Lille at the Inserm U1283 / CNRS UMR 8199 - “Functional (Epi)genomics and Molecular Physiology of Diabetes and Related Diseases” as the head of the biostatistics team.

Education

Doctor of Philosophy (Ph.D.) in Biostatistics

University of Lille

Lille, France

Oct. 2014 - Sep. 2017

Thesis: Development and Application of Statistical Methods for Multi-Omics Studies in Type 2 Diabetes: Beyond the Genome-Wide Association Studies Era

Master’s Degree in Biostatistics, Bioinformatics and Genomics (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2009 - Jul. 2011

Internships:

  • Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward (3 months)
  • Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data (6 months)

Bachelor’s Degree in Biology (Specialised in Biostatistics)

University Claude Bernard Lyon 1

Lyon, France

Sep. 2006 - Jul. 2009

Professional & Research Experience

Head of the Biostatistics Team (Institut Pasteur de Lille)

Functional (Epi)genomics and Molecular
Physiology of Diabetes and Related Diseases
Inserm U1283 / CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Jan. 2020 - Present

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Head of the Biostatistics Team (Institut Pasteur de Lille)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Oct. 2017 - Dec. 2019

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Head of the Biostatistics Team (CNRS)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Jan. 2016 - Sep. 2017

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management

Biostatistician (CNRS)

Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)

Lille, France

Sep. 2012 - Dec. 2015

Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments

Biostatistician

French Institute of Science and Technology for
Transport, Development and Networks
(IFSTTAR)
UMRESTTE - UMR T9405

Bron, France

Nov. 2011 - Dec. 2011

Activities: Analysis of a mobility and accident study in secondary-school pupils

Biostatistician (Internship)

Hospices Civiles de Lyon
Biostatistics Unit
CNRS UMR 5558

Lyon, France

Jan. 2011 - Jun. 2011

Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data

Biostatistician (Internship)

Biometry and Evolutionary Biology laboratory
(LBBE)
CNRS UMR 5558

Lyon, France

Mar. 2010 - Jun. 2010

Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward

Workshop Experience (6)

R Advanced

Half-day workshop (in French)

Lille, France

Nov. 2020

ggplot2

Half-day workshop (in French)

Lille, France

Oct. 2020

R Statup

Thirty minutes introduction (in French)

Lille, France

Oct. 2020

R Packages

Thirty minutes overview (in English

Lille, France

Feb. 2020

Shiny: First Steps

One-day workshop (in French)

Lille, France

Nov. 2019

R and Databases

Two-days workshop (in French)

Lille, France

May 2018

Awards (1)

Funding Allocation SFD-Lilly

“Société Francophone du Diabète”
(SFD)

Bordeaux, France

Mar. 2015

Project: Detection of new genomic variants associated with fasting blood glucose and incidence of type 2 diabetes simultaneously

Oral communications (3)

Jointly Modelling SNPs With Survival & Longitudinal Trait

A Statistical Seminar Applied on Type 2 Diabetes (Host: Pr. Paul Franks)

Lund, Sweden

Jan. 2019

Jointly Modelling SNPs With Survival & Longitudinal Trait

Thematic Day “Statistic & Genomic”
of the “Réseau Interdisciplinaire
autour de la Statistique”
(RIS)

Paris, France

Oct. 2018

Longitudinal Genetic Modelling: Revisiting Associations of SNPs Associated With Blood Fasting Glucose in Normoglycemic Individuals

Statistical Methods for Post Genomic Data
(SMPGD)

Lille, France

Feb. 2016

Poster communications (4)

“Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint” (CA-075)

Annual Congress of
“Société Francophone du Diabète”
(SFD)

Lille, France

Mar. 2017

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

4th Symposium
European Genomic Institute for Diabetes
(EGID)

Lille, France

Nov. 2016

Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach

International Genetic Epidemiology Society
(IGES)

Toronto, Canada

Oct. 2016

Application of Joint Models in Genetic Association Studies

International Genetic Epidemiology Society
(IGES)

Baltimore, United-States

Oct. 2015

R Packages (10)

insane: An Interactive Web Application for Quality Control and Analysis of Insulin Secretion from Pancreatic Beta Cells

(As author / creator)

CRAN

Nov. 2020

https://cran.r-project.org/package=insane
https://github.com/mcanouil/insane/

CRAN_Status_Badge
GitHub_tag

ggpacman: A ‘ggplot2’ and ‘gganimate’ Version of Pac-Man

(As author / creator)

CRAN

May 2020

https://cran.r-project.org/package=ggpacman
https://github.com/mcanouil/ggpacman/

CRAN_Status_Badge
GitHub_tag

dmapaq: DNA Methylation Arrays Processing And Quality-Control

(As author / creator)

GitHub

Mar. 2020

https://github.com/umr1283/dmapaq/

GitHub_tag

dgapaq: DNA Genotyping Arrays Processing And Quality-Control

(As author / creator)

GitHub

Mar. 2020

https://github.com/umr1283/dgapaq/

GitHub_tag

ggnetwork: Geometries to Plot Networks with ‘ggplot2’

(As contributor)

CRAN

Feb. 2020

https://cran.r-project.org/package=ggnetwork
https://github.com/briatte/ggnetwork/

CRAN_Status_Badge
GitHub_tag

rain: Reference-based Ancestry Inference

(As author / creator)

GitHub

Jan. 2020

https://github.com/umr1283/rain/

GitHub_tag

MiSTr: Mixed effects Score Test

(As contributor / creator)

GitHub

Nov. 2019

https://github.com/mcanouil/MiSTr/

GitHub_tag

NACHO: NanoString Quality Control Dashboard

(As author / creator)

CRAN

Jun. 2018

https://cran.r-project.org/package=NACHO
https://github.com/mcanouil/NACHO/

CRAN_Status_Badge
GitHub_tag

clere: Simultaneous Variables Clustering and Regression

(As author)

CRAN

Feb. 2014

https://cran.r-project.org/package=clere
https://github.com/mcanouil/clere/

CRAN_Status_Badge
GitHub_tag

snpEnrichment: SNPs Enrichment Analysis

(As author / creator)

CRAN

Apr. 2013

https://cran.r-project.org/package=snpEnrichment
https://github.com/mcanouil/snpEnrichment/

CRAN_Status_Badge
GitHub_tag

Publications (30)

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, […], Mickaël Canouil32/36, Philippe Froguel, Decio L. Eizirik, Miriam Cnop and Piero Marchetti

N/A

Dec. 2020

Monogenic Diabetes Characteristics in a Transnational Multicenter Study From Mediterranean Countries

Martine Vaxillaire, Amélie Bonnefond, Stavros Liatis, Leila Ben Salem Hachmi, Aleksandra Jotic, […], Mickaël Canouil11/24, […], Doros Loizou, Nebojsa Lalic, Josanne Vassallo, Michel Marre and Philippe Froguel

N/A

Nov. 2020

Pathogenic Variants in Actionable MODY Genes are Associated with Type 2 Diabetes

Amélie Bonnefond, Mathilde Boissel, Alexandre Bolze, Emmanuelle Durand, Bénédicte Toussaint, […], Martine Vaxillaire, Mickaël Canouil24/27, Nicole L. Washington, Joseph J. Grzymski and Philippe Froguel

N/A

Oct. 2020

Gene-Educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci

Lifelines Cohort Study, Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, […], Mickaël Canouil75/223, […], Paul Elliott, Patricia B. Munroe, Paul W. Franks, Dabeeru C. Rao and Myriam Fornage

N/A

May 2020

General Regression Model: A “Model-Free” Association Test for Quantitative Traits Allowing to Test for the Underlying Genetic Model

Emilie Gloaguen, Marie-Hélène Dizier, Mathilde Boissel, Ghislain Rocheleau, Mickaël Canouil5/11, […], Jean Tichet, Ronan Roussel, Cécile Julier, Beverley Balkau and Flavie Mathieu

N/A

Dec. 2019

Loss-of-Function Mutations in MRAP2 Are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension

Morgane Baron, Julie Maillet, Marlène Huyvaert, Aurélie Dechaume, Raphaël Boutry, […], Mehdi Derhourhi, Stefan Gaget, Mickaël Canouil29/31, Philippe Froguel and Amélie Bonnefond

N/A

Nov. 2019

The Expression of Genes in Top Obesity-Associated Loci Is Enriched in Insula and Substantia Nigra Brain Regions Involved in Addiction and Reward

Fatou K. Ndiaye, Marlène Huyvaert, Ana Ortalli, Mickaël Canouil4/17, Cécile Lecoeur, […], Michel Marre, Ronan Roussel, Beverley Balkau, Philippe Froguel and Amélie Bonnefond

N/A

Aug. 2019

NACHO: An R package for Quality Control of NanoString nCounter Data

Mickaël Canouil, Gerard A. Bouland, Amélie Bonnefond, Philippe Froguel, Leen M. ’t Hart and Roderick C. Slieker

N/A

Aug. 2019

Bioinformatics

As first or co-first author.

Genome-Wide Association Study of Change in Fasting Glucose Over Time in 13,807 Non-Diabetic European Ancestry Individuals

Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S. Benke, […], Mickaël Canouil7/50, […], Inês Barroso, Inga Prokopenko, Josée Dupuis, James B. Meigs and Nabila Bouatia-Naji

N/A

Jul. 2019

A Trans-Ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

Jonathan P. Bradfield, Suzanne Vogelezang, Janine F. Felix, Alessandra Chesi, Øyvind Helgeland, […], Mickaël Canouil41/99, […], Nicholas J. Timpson, Stefan Johansson, Hakon Hakonarson, Vincent W. V. Jaddoe and Struan F. A. Grant

N/A

Jul. 2019

A Catalog of Genetic Loci Associated with Kidney Function From Analyses of a Million Individuals

Matthias Wuttke, Yong Li, Man Li, Karsten B. Sieber, Mary F. Feitosa, […], Mickaël Canouil51/327, […], Iris M. Heid, Markus Scholz, Alexander Teumer, Anna Köttgen and Cristian Pattaro

N/A

Jun. 2019

Multi-Ancestry Genome-Wide Gene–Smoking Interaction Study of 387,272 Individuals Identifies New Loci Associated with Serum Lipids

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, […], Mickaël Canouil97/301, […], Patricia B. Munroe, Alanna C. Morrison, Dabeeru C. Rao, Charles N. Rotimi and L. Adrienne Cupples

N/A

Apr. 2019

A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci for Pulse Pressure and Mean Arterial Pressure

Yun Ju Sung, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, […], Mickaël Canouil95/282, […], Mark J. Caulfield, W. James Gauderman, Patricia B. Munroe, Dabeeru C. Rao and Alanna C. Morrison

N/A

Apr. 2019

Laser Capture Microdissection of Human Pancreatic Islets Reveals Novel eQTLs Associated with Type 2 Diabetes

Amna Khamis, Mickaël Canouil2/20, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, […], Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena and Philippe Froguel

N/A

Mar. 2019

Molecular Metabolism

As first or co-first author.

Multi-Ancestry Study of Blood Lipid Levels Identifies Four Loci Interacting with Physical Activity

Lifelines Cohort Study, Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, […], Mickaël Canouil75/230, […], L. Adrienne Cupples, Charles N. Rotimi, Alanna C. Morrison, Dabeeru C. Rao and Ruth J. F. Loos

N/A

Jan. 2019

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil81/266, […], Kenneth Rice, Daniel I. Chasman, L. Adrienne Cupples, Dabeeru C. Rao and Alanna C. Morrison

N/A

Jan. 2019

Fine-Mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation and Islet-Specific Epigenome Maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, […], Mickaël Canouil35/115, […], Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke and Mark I. McCarthy

N/A

Oct. 2018

Type 2 Diabetes–Associated Variants of the MT2 Melatonin Receptor Affect Distinct Modes of Signaling

Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, […], Mickaël Canouil9/17, […], Viktoria Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier and Ralf Jockers

N/A

Aug. 2018

Jointly Modelling Single Nucleotide Polymorphisms with Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose

Mickaël Canouil, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau

N/A

Jun. 2018

Frontiers in Genetics

As first or co-first author.

Novel Genetic Associations for Blood Pressure Identified via Gene-Alcohol Interaction in up to 570K Individuals Across Multiple Ancestries

Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil87/274, […], Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province and Daniel Levy

N/A

Jun. 2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes

Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil4/38, Stéphane Cauchi, […], Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou and Philippe Froguel

N/A

May 2018

Diabetes

As first or co-first author.

Refining the Accuracy of Validated Target Identification Through Coding Variant Fine-Mapping in Type 2 Diabetes

Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, […], Mickaël Canouil68/243, […], Michael Boehnke, Danish Saleheen, Andrew P. Morris, Jerome I. Rotter and Mark I. McCarthy

N/A

Apr. 2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Yun J. Sung, Thomas W. Winkler, Lisa de Las Fuentes, Amy R. Bentley, Michael R. Brown, […], Mickaël Canouil94/301, […], Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao and Daniel I. Chasman

N/A

Mar. 2018

Expression and Functional Assessment of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing to Human Insulin Secretion

Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil3/22, Marlène Huyvaert, Clara Salazar-Cardozo, […], Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel and Amélie Bonnefond

N/A

Jun. 2017

Molecular Metabolism

As first or co-first author.

Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles

Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel and Odile Poulain-Godefroy

N/A

Jun. 2017

PloS One

As first or co-first author.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J. Gaulton, […], Mickaël Canouil10/26, […], Anna L. Gloyn, Philippe Froguel, Michele Solimena, Mark I. McCarthy and Guy A. Rutter

N/A

Feb. 2017

Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach

Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil4/20, Maxime Castelain, […], Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau and Philippe Froguel

N/A

Feb. 2017

Hepatic DPP4 DNA Methylation Associates with Fatty Liver

Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, […], Mickaël Canouil7/17, […], Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann and Robert W. Schwenk

N/A

Jan. 2017

Variable Clustering in High-Dimensional Linear Regression: The R Package

Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil

N/A

Apr. 2016